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New and Improved Skulpt
Although Skulpt has been a popular spot reduction spray for those stubborn
fatty areas that just won’t seem to go away, there was one minor knock on
this powerfully potent tool. For people with fair skin, Skulpt temporarily
stained targeted areas and in some cases also rubbed off on clothing. Although
it easily washed away in both cases, ErgoPharm was determined to perfect
Skulpt. They went back to the lab in order to provide a superior product
with no pesky side effects whatsoever. The result, the same industrial strength
spot reducer with no bothersome staining on you or your clothing.
Let’s clarify Skulpt’s serving size/doses per bottle
7 sprays two times per day equals 30 day supply at maximum dose.
Topical Fat Loss Spray
Topically applied products meant for localized fat loss of problem areas
have been on the market for a few years now. These products contain lipolytic
ingredients such as yohimbine hydrochloride, aminophylline, and forskolin.
The intention of these products is to deliver the active ingredients through
the skin and into the subcutaneous adipose tissue, where they will then act
to break down and remove the fat (a process called “lipolysis”).
While somewhat effective, these products suffer from some insufficiencies
that prevent the formulations from exhibiting their full potential. I will
present to you what these insufficiencies are, and also the solutions to
these insufficiencies – solutions that ErgoPharm has now incorporated into
Skulpt.
Free base versus hydrochloride salts.
Here I present to you a little chemistry lesson. The topic of this lesson
is the properties of a class of compounds called
alkaloids. Alkaloids
are natural compounds from plants that contain a basic (as in alkaline) nitrogen
atom in their chemical structure. Examples of alkaloids are:
In nature, alkaloids exist in their “free base” form. However, since alkaloids
contain basic nitrogen atoms, they can also form crystalline salts with acids
such as hydrochloric acid. For instance, the addition of hydrochloric acid
to ephedrine gives ephedrine hydrochloride
Alkaloid acid salts (such as hydrochloride) are usually the preferred form
of alkaloids that people deal with because they are usually high melting,
stable, and crystalline – as opposed to the free bases which are often low
melting, somewhat unstable, and often semi-solid (sometimes even liquid).
The hydrochloride salts are also quite water soluble, as opposed to the free
bases that have very poor water solubility – but high lipid solubility. This
high water solubility is often a big advantage for pharmacists and chemists
under certain circumstances, however for the purposes of transport through
the skin (as in a topical spray) this high water solubility and low lipid
solubility is
not desirable.
In the case of delivering alkaloids through the skin we want to use the
free base form, not the hydrochloride salt form.
Why is this? Simple – the barrier layer of the skin (stratum corneum) is
composed of dead skin cells surrounded by channels comprised primarily of
lipids. Obviously we want something that can dissolve through these lipid
channels and penetrate this natural barrier. Hydrochloride salts cannot do
this well, free bases can.
It is for this reason that the alkaloid content of Skulpt – which includes
yohimbine and octopamine – are present within the formula in free base form.
Mind you, this is not an easy thing to do. Yohimbine is notoriously unstable
in the free base form. ErgoPharm had to conduct extensive research into finding
a formula that would allow the free base yohimbine to exist with a reasonable
shelf life. Fortunately we were successful, and the end result is the premier
topical fat loss formula — Skulpt.
A topical fat loss formula can have the best active ingredients at the best
ratios yet if the vehicle it is delivered in is not able to assist in their
penetration through the skin and into the subcutaneous fat then the product
will be a failure.
The use of penetration enhancers such as IPM, Azone, and salicylic acid can
be used (alone or in combination) to enhance the diffusion of active lipolytic
compounds through the skin. While effective, none of these enhancers are
as potent as the gold standard of penetration enhancers – dimethylsulfoxide
(DMSO).
So why don’t people just use DMSO in their formulas? There are a couple of
good reasons for this. Standard DMSO is quite irritating to the skin (especially
in high concentrations). Its continued use often leads to irritation, rashes,
and skin peeling. Another compelling reason not to use DMSO is its awful
smell and taste. DMSO has a somewhat foul garlicky odor, but not only that,
after rubbing it on your skin it quickly penetrates into your blood and travels
to your lungs and mouth where it leads to the dreaded “DMSO breath”. These
are not things most people are willing to put up with.
Interestingly enough, it actually is not the DMSO itself that is responsible
for these nasty effects; it is impurities present in the DMSO – foul smelling
and caustic sulfur containing compounds that exist in very small concentrations.
Pure DMSO is actually odorless and tasteless!!
The problem is it is also extraordinarily expensive. Pure DMSO (DMSO USP)
costs
20 times as much as regular DMSO!! It is worth it however;
as it makes a topical formula extraordinarily effective, while simultaneously
being free of excessive irritation, foul odor, and bad breath related problems.
ErgoPharm uses DMSO USP in Skulpt, and it is in fact the most expensive single
component of the whole product!! We had to put it in there though, because
we were determined to make the best product regardless of cost. We also are
well aware that our consumers are intelligent people, and they understand
that there is truth to the old adage “you get what you pay for”
Estrogen suppression complex – Skulpt’s special bonus
AntiGyno!!
In addition to ingredients designed to enhance localized fat loss, ErgoPharm
decided to also include an effective amount of a potent aromatase inhibitor
— 6-OXO— in the Skulpt formula.
In males and post-menopausal females, the main site of estrogen formation
(aromatization) occurs in the adipose tissue. With this fact in mind, ErgoPharm
decided that it would make sense to include an aromatase inhibition component
to Skulpt. By including this we not only attack the subcutaneous fat, but
we also attack the main site of estrogen formation in the body. The end result
is a reduction in the level of subcutaneous fat coupled with a positive effect
on the body’s endocrinological balance.
The inclusion of the estrogen suppression - 6-OXO, also opens up a whole
new use for Skulpt as an “anti-gyno” tool. It is aromatization in the breast
area that is responsible for the formation of the ugly and dreaded bitch
tits. This growth of the breast tissue in men can occur naturally, however
it is most common in men using anabolic steroids, or certain prohormone products.
The use of Skulpt applied to the lower pectoral region can deliver estrogen
suppressing ingredients directly to the breast glands and surrounding estrogen
sensitive fatty tissue. The result is a substantial increase in the leanness
of the area, and a very noticeable improvement in the definition of the lower
and outer pectorals.